Epilepsy is associated with poor brain health, with a consistent deleterious effect seen on cognitive and motor function and mental health.

The Florey Dementia Index (FDI) is valid for predicting the age of onset of mild cognitive impairment (MCI) and Alzheimer disease (AD).

There are disparities in traumatic brain injury (TBI)-related mortality, with the highest rates seen for older adults, men, and non-Hispanic American Indian/Alaska Native persons.