Background: Subclinical hypothyroidism has been linked to adverse renal outcomes, but it is unknown whether treatment of subclinical hypothyroidism reduces the risk of these adverse outcomes. We ...

Key points Canada’s health systems are stressed with increasing demands for health care and services. The causes of this stress are multifactorial and include an aging population and a health ...

Key points The provision of health care is hard and, understandably, clinicians struggle. Beyond meaningful health care interactions, clinicians must also integrate large volumes of demographic, ...

Care should include explicit statements affirming patient choice. Clinicians with faith-based objections should provide timely, tolerant referral; judgmental or obstructive care may result in ...

Background: The relation between emergency department opioid prescribing and subsequent harm is complex and poorly studied. We sought to quantify adverse outcomes, incremental risk, and rates of ...

KEY POINTS Physical activity is a modifiable risk factor for more than 30 chronic conditions relevant to the older adult; 150 minutes per week of moderate physical activity can reduce all-cause ...

Diet is associated with depressive symptoms A 2024 umbrella review — including nearly 10 million participants enrolled in observational studies — found that people who consumed more ultra-processed ...

Acro-osteolysis refers to resorption of the distal phalanx. The most common causes include connective tissue disorders (scleroderma and psoriatic arthritis), occupational exposures (polyvinyl chloride ...

Background: The implementation and clinical impact of machine learning–based early warning systems for patient deterioration in hospitals have not been well described. We sought to describe the ...

Transgender people face many formal barriers to gender-affirming care, sometimes known as “gatekeeping.” Gender-affirming care refers to a wide range of medical interventions that patients pursue to ...

Wildfire seasons are getting longer and more severe in Canada. Wildfire smoke caused 710 emergency department visits for respiratory conditions and 250 for cardiac conditions in 2017.[1][1] During ...

Figure 1: (A) Peripheral blood smear showing erythrocytes with basophilic stippling (arrows) in a 47-year-old male plumber with lead poisoning. (B) Burton line (arrows) in some of the patient’s gum ...