These nicks enabled the DNA to rotate more easily and release built-up tension, which, in turn, caused fewer plectonemes to form. This confirmed that torsional stress is a key driver of these ...

A new study published in Nature Structural & Molecular Biology reveals how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that ...

The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by a UCL-led research team. DNA is widely accepted to be formed of two strands that wind around one ...

Rosalind Franklin’s role in the discovery of the structure of DNA may have been different than previously believed. Franklin wasn’t the victim of data theft at the hands of James Watson and Francis ...

Researchers have unveiled a new type of nanostructure that dramatically improves CRISPR delivery. Called lipid nanoparticle ...

A multi-institutional team led by researchers at Baylor College of Medicine says that genomic structural variation is an unappreciated mechanism involved in altering DNA methylation. They published ...

A robust platform for analyzing 3D genome architecture and epigenomic features enables a deeper understanding of gene regulation in specific cell types. Researchers analyze various aspects of gene ...

Researchers at Imperial College London have discovered that an unusual DNA structure could be key to reversing chemotherapy resistance in ovarian cancer, one of the deadliest cancers affecting women ...