The Guardians took the second of the four-game series with the Orioles, 6-3, a day after winning the opener, 10-5. Cleveland is on a three-game winning streak, 4-1 in the past five and 8-2 over the last 10, so the Guardians are getting hot, while the O’s are 1-6 in the last seven.

The Cleveland Guardians defeated the Baltimore Orioles 6-3 in a competitive Orioles vs Guardians matchup on July 22, 2025, at Progressive Field, as seen in the sports card above. José Ramírez’s first-inning home run set the tone,

Coby Mayo, as young as he is, understands the business as the Orioles falter heading into the MLB trade deadline.

Angel Martínez had three hits, José Ramírez homered and the Cleveland Guardians defeated the Baltimore Orioles 6-3 Tuesday night for their fourth win in five games since the All-Star break. Kyle Manzardo and Bryan Rocchio each drove in a pair of runs as the Guardians have won 10 of 12 after a 10-game losing streak to get back to .500 at 50-50.

The Baltimore Orioles have added some additional depth into their bullpen. As first reported by Roch Kubatko of MASN, the Orioles are bringing back veteran reli

If I'm playing the general manager for the Baltimore Orioles right now, I'm wondering how I allowed this to happen after a massive rebuild and frankly, I'm worried about my job security. I tried to save face by firing manager Brandon Hyde,

This affiliate content is not influenced by our advertising relationships, but AP and Data Skrive might earn commissions from our partners’ links in this content.

Upcoming Baltimore Orioles game When is the next Baltimore Orioles game? Tuesday, July 22 Who are they playing? Cleveland Guardians

Jose Ramirez hit a three-run homer and Bo Naylor and Kyle Manzardo had solo shots as the Cleveland Guardians beat the visiting Baltimore Orioles 10-5 in their series opener Monday night.