Hantaviral Proteins: Structure, Functions, and Role in Hantavirus ...
WEBNov 27, 2015 · Understanding structure of the Hantavirus genome and the functions of the key viral proteins are critical for the therapeutic agents’ research. This paper gives a brief overview of the current knowledge on the structure and properties of the Hantavirus nucleoprotein and the glycoproteins.
Hantavirus Replication Cycle—An Updated Structural Virology …
WEBAug 6, 2021 · In this review, we summarize our current understanding of the molecular and structural biology of the hantavirus replication cycle, focusing on recent insights from structural virology studies. We discuss somewhat contradictory hypotheses regarding hantavirus entry, replication, and assembly.
Structures of active Hantaan virus polymerase uncover the …
WEBMay 23, 2023 · Here we describe the structure of the Hantaan virus polymerase core and establish conditions for in vitro replication activity. The apo structure adopts an inactive conformation that involves...
Hantavirus entry: Perspectives and recent advances - PMC
WEBHantaviruses are emerging rodent-borne pathogens whose accidental human transmission causes Hemorrhagic Fever with Renal Syndrome (HFRS) in the Old World and Hantavirus Pulmonary Syndrome (HPS) in the New World (Vaheri et al., 2013).
Hantavirus structure--molecular interactions behind the scene
WEBWe attempt to summarize recent results on the virion structure and to suggest mechanisms on how the assembly is driven. We also compare hantaviruses to other bunyaviruses with known structure.
The Hantavirus Surface Glycoprotein Lattice and Its Fusion …
WEBSep 15, 2020 · Hantavirus particles are pleomorphic and display a characteristic square surface lattice. The envelope glycoproteins Gn and Gc form heterodimers that further assemble into tetrameric spikes, the lattice building blocks.
Hantavirus structure--molecular interactions behind the scene.
WEBAug 1, 2012 · We also compare hantaviruses to other bunyaviruses with known structure. This review focuses on the structural components of hantaviruses, their interactions, the mechanisms behind virion assembly and the interactions that maintain virion integrity.
Uncovering the mysteries of hantavirus infections - Nature
WEBJul 16, 2013 · Key Points. Hantaviruses are negative-sense single-stranded RNA viruses that infect many species of rodents, shrews, moles and bats. Hantaviruses primarily replicate in the endothelium and...
Structural characterization of the oligomerization of full-length ...
WEBMar 13, 2024 · Here, the authors unveil the structure of the full-length Hantaan virus polymerase in monomeric, dimeric and hexameric apo forms, revealing the multimerization capability of this enzyme.
Structure of the Hantavirus Nucleoprotein Provides Insights into …
WEBThe nucleoprotein (N) of hantavirus is essential for viral transcription and replication, thus representing an attractive target for therapeutic intervention. We have determined the crystal structure of hantavirus N to 3.2 Å resolution.
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